Juvenile ossifying fibroma: a case report
DOI:
https://doi.org/10.5335/rfo.v26i1.12928Keywords:
Benign fibro-osseous lesions; Ossifying fibroma; Juvenile trabecular ossifying fibroma; craniofacial osteosarcoma.Abstract
Objective: juvenile Trabecular Ossifying Fibromas
(JTOF) are uncommon benign fibro-osseous lesions
with a local aggressive behavior. They frequently
occur in children and adolescents involving the
jaw bones. This report addresses the clinical, imaging, histopathological, and immunohistochemical aspects and the treatment of a case of JTOF.
In addition, it discusses similarities between JTOF
and low-grade osteosarcomas and alternatives for
their diagnosis. Case report: male patient, 12 years
old, with a tumor in his left mandible, loss of masticatory function and speech, with a 6-month time
course. Radiographically, the lesion had an unilocular aspect, with defined borders and a mixed
image pattern. Treatment consisted surgical enucleation, followed by bone curettage, under general anesthesia. Histopathology presented fibrous
stroma interspaced with bone trabeculae without
signs of cellular malignancy. MDM2 and CDK4
markers in immunohistochemistry, confirmed the
diagnosis of JTOF and excluded low-grade osteosarcoma. At the 20-day postoperative follow-up,
the patient reported improvement in paresthesia,
masticatory function and speech, and the absence
of pain. Evaluation 1 year after surgery showed no
signs of local recurrence. Final considerations: the
similarity of clinical, imaging, and microscopic aspects between JTOF and low-grade osteosarcoma
prompts an immunohistochemical study including
MDM2 and CDK4 markers in order to improve final diagnosis and guide the treatment plan more
efficiently.
Keywords: benign fibro-osseous lesions; ossifying
fibroma; juvenile trabecular ossifying fibroma;
craniofacial osteosarcoma.
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