Drug interactions of interest in dentistry
DOI:
https://doi.org/10.5335/rfo.v24i1.8807Keywords:
Pharmacology, Drug interactions, DentistryAbstract
Objective: to highlight the importance of pharmacological knowledge in dentistry and to identify the main drug interactions that may occur in this area, providing information for a safer and more effective prescription. Literature review: It is possible to observe that the most prescribed classes in dental practice are NSAIDs, antibiotics and analgesics. The most significant interactions with NSAIDs occur with anticoagulants (which cause increased risk of bleeding), antihypertensive drugs (which reduce anti-hypertensive efficacy) and lithium, which increase the toxicity of this drug. In addition, NSAIDs may interact with drugs such as Efavirenz or Naltrexone, which increase the risk of liver damage. For antibiotics, the most common interactions take place with ethanol, (which may lead to disulfiram-like reactions), ethinyl estradiol (which compromise contraceptive efficacy); in addition to important interactions with anticoagulants, isotretinoin and methotrexate. Opioids, associated with benzodiazepines or other depressants such as amitriptyline, may result in heavy sedation; while interaction with fluoxetine may decrease analgesia. Final considerations: there is a significant possibility of drug interactions in dentistry, which may compromise patients' health. The dental surgeon's knowledge about possible interactions and their potential risks is important in order to avoid complications during treatment.
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