Oral Contact Stomatitis: Recognizing Toothpaste as a Potential Trigger

Abstract

Contact allergic stomatitis is an inflammatory reaction of the oral mucosa triggered by allergens frequently found in oral hygiene products. This condition can present with non-specific symptoms, often mimicking other oral diseases, making diagnosis challenging. Objective: The objective of this report is to highlight the clinical features, diagnostic challenges, and management of contact allergic stomatitis through a series of four illustrative cases. Case Report: Four female patients, aged 28 to 49, presented with oral symptoms including xerostomia, burning sensation, erythema, edema, and lip fissures. All patients reported symptom onset shortly after beginning the use of a newly reformulated toothpaste. Detailed clinical histories were obtained, laboratory tests were performed, and other inflammatory and autoimmune conditions were ruled out. In all cases, symptoms appeared immediately after oral hygiene practices and improved significantly following discontinuation of the suspected toothpaste. Final Considerations: The presented cases illustrate the need for greater clinical awareness of contact allergic stomatitis as a possible consequence of the use of new or reformulated oral hygiene products. Early identification and elimination of the causative agent can lead to rapid resolution of symptoms and prevent misdiagnosis. Ongoing research and the development of diagnostic protocols are essential to support clinicians in managing this still underrecognized condition and to ensure patient well-being.