Use of the growth hormone associated with injectable platelet-rich fibrin (I-PRF)
DOI:
https://doi.org/10.5335/rfo.v24i2.10460Keywords:
Platelet-derived growth factor (PDGF), Platelet-rish fibrin and leococites (L-PRF), Injectable platelet-rich fibrin (I-PRF), Growth hormone (GH), Bone transplantsAbstract
Objective: this study aims to show through a literature review the use of the growth hormone and platelet concentrates and to suggest an association technique for dentistry use in alveolar bone preservation processes. Literature review: bone grafts are a health requirement for a number of reasons. The use of autogenous bone has the main disadvantage of a second surgical site, while bone substitutes do not present optimal characteristics. Thus, there is a search for alternatives that optimize the healing and incorporation of bone substitutes, which include blood concentrates that are rich in platelet-derived growth factors and the growth hormone. A vast literature can be found on blood concentrates, including their use as vehicles to other substances. Blood concentrates are rich in platelet-derived growth factors such as IGF, PDGF, and others. Moreover, the literature also shows the topical use of the growth hormone in bone grafts, fractures, and dental implants. However, the growth hormone presents a half-life of 20 minutes; therefore, when combined with I-PRF, an increased time in local action is expected. Final considerations: it is possible to optimize bone grafts by using L-PRF/I-PRF and the growth hormone. However, further research is required.
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References
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16. Lucarelli E, Beccheroni A, Donati D, Sangiorgi L, Cenacchi A, Vento AM, et al. Platelet-derived growth factors enhance proliferation of human stromal stem cells. Biomaterials 2003; 24(18):3095-100.
17. Butt AJ, Firth SM, Baxter RC. The IGF axis and programmed cell death. Immunol Cell Biol 1999; 77(3):256-62.
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19. Miron RJ, Fujioka-Kobayashi M, Hernandez M, Kandalam U, Zhang Y, Ghanaati S, et al. Injectable platelet rich fibrin (i-PRF): opportunities in regenerative dentistry? Clin Oral Invest 2017; 21(8):2619-27.
20. Miron RJ, Zhang Y. Autologous Liquid Platelet Rich Fibrin: a novel drug delivery system. Acta Biomater 2018; 15(75):35-51.
21. Guyton AC, Hall JE. Textbook of Medical Physilogy. 11. ed. Philadelphia: Saunders; 2006.
22. Eriksen E, Kassem M, Langdahl B. Growth hormone, insulin-like growth factors and bone remodelling. Eur J Clin Invest 1996; 26(7):525-34.
23. Varkey M, Gittens SA, Uludag H. Growth factor delivery for bone tissue repair: an update. Expert Opin Drug Deliv 2005; 1(1):19-36.
24. Simpson A, Mills L, Noble B. The role of growth factors and related agents in accelerating fracture healing. J Bone Joint Surg Br 2006; 88(6):701-5.
25. Calvo-Guirado J, Mate-Sanchez J, Delgado-Ruiz R, RamirezFernández M, Cutando-Soriano A, Peña M. Effects of growth hormone on initial bone formation around dental implants: a dog study. Clin Oral Implants Res 2011; 22(6):587-93.
26. Bail H, Klein P, Kolbeck S, Krummrey G, Weiler A, Schmidmaier G, et al. Systemic application of growth hormone enhances the early healing phase of osteochondral defects – a preliminary study in micropigs. Bone 2003; 32(5):457-67.
27. Tresguerres IF, Blanco L, Clemente C, Tresguerres JA. Effects of local administration of growth hormone in peri-implant bone: an experimental study with implants in rabbit tibiae. Int J Oral Maxillofac Implants 2003; 18(6):807-11.
28. Pagnoncelli R, da Gerzson A, Camilotti R, Jasper J, Böing F. Hormônio do crescimento humano e a perspectiva futura em Odontologia. Rev Fac Odontol Univ Passo Fundo 2014; 19(3):379-83.
29. Clark R. Fibrin and Wound Healing. Ann NY Acad Sci 2001; 936(1):355-67.
30. Shah R, Gowda T, Thomas R, Kumar T, Mehta D. Biological activation of bone grafts using injectable platelet-rich fibrin. J Prosthet Dent 2018; 121(3):391-3
31. Fujioka-Kobayashi M, Miron RJ, Hernandez M, Kandalam U, Zhang Y, Choukroun J. Optimized Platelet-Rich Fibrin With the Low-Speed Concept: Growth Factor Release, Biocompatibility, and Cellular Response. J Periodontol 2017; 88(1):112-21.
32. Guicheux J, Gauthier O, Aguado E, Pilet P, Couillaud S, Jegou D, et al. Human Growth Hormone Locally Released in Bone Sites by Calcium-Phosphate Biomaterial Stimulates Ceramic Bone Substitution Without Systemic Effects: A Rabbit Study. J Bone Miner Res 1998; 13(4):739-48.
33. Gómez-Moreno G, Cutando A, Arana C, Worf C, Guardia J, Muñoz F, et al. The effects of growth hormone on the initial bone formation around implants. Int J Oral Maxillofac Implants 2009; 24(6):1068-73.
34. Tresguerres IF, Clemente C, Donado M, Gómez-Pellico L, Blanco L, Alobera M, et al. Local administration of growth hormone enhances periimplant bone reaction in an osteoporotic rabbit model. Clin Oral Implants Res 2002; 13(6):631-6.
35. Webster R, Xie R, Didier E, Finn R, Finnessy J, Edgington A, et al. PEGylation of somatropin (recombinant human growth hormone): Impact on its clearance in humans. Xenobiotica 2008; 38(10):1340-51.
36. Mullis PE, Pal RB, Matthews DR, Hindmarsh PC, Phillips PE, Dunger DB. Half-life of exogenous growth hormone following suppression of endogenous growth hormone secretion with somatostatin in type I (insulin-dependent) diabetes mellitus. Clin Endocrinol 1992; 36(3):255-63.
37. Lanzi R, Andreotti A, Caumo A, Manzoni M, Losa M, Malighetti M, et al. Assessment of growth hormone (GH) plasma clearance rate, half-life, and volume of distribution in acromegalic patients: the combined GH-octreotide infusion. J Clin Endocrinol Metabolism 1995; 80(11):3279-83.
38. Gerzson A, Machado D, Marinovic D, Pagnoncelli R. Assessment of Adhesion and Proliferation of Bone Marrow Mesenchymal Stem Cells in Polymer Matrices with rhGH. Int J Oral Maxillofac Implant. 2017; 32(3):e183-9.
39. Yang H, La WG, Cho YM, Shin W, Yeo GD, Kim BS. Comparison between heparin-conjugated fibrin and collagen sponge as bone morphogenetic protein-2 carriers for bone regeneration. Exp Mol Medicine 2012; 44(5):350-5.
40. Polak D, Clemer-Shamai N, Shapira L. Incorporating antibiotics into platelet-rich fibrin: A novel antibiotics slow-release biological device. J Clin Periodontol 2019; 46(2):241-7.
41. Hindmarsh PC, Dattani MT. Use of growth hormone in children. Nat Clin Pract Endoc 2006; 2(5):260-8.
2. Miron RJ, Zhang YF. Osteoinduction. J Dent Res 2011; 91(8):736-44.
3. Chokroun J, Adda F, Schoeffloer C, Vervelle A. Une opportunit en paro implantologie, le PRF. Implantodontie 2001; 42:55-62.
4. Harvey S, Hull K. Growth hormone. Endocrine 1997; 7(3):267-79.
5. Haimov H, Yosupov N, Pinchasov G, Juodzbalys G. Bone Morphogenetic Protein Coating on Titanium Implant Surface: a Systematic Review. J Oral Maxillofac Res 2017; 8(2):e1.
6. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, et al. Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part I: Technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006; 101(3):e37-44.
7. Dhurat R, Sukesh. Principles and methods of preparation of platelet-rich plasma: A review and author’s perspective. J Cutan Aesthetic Surg 2014; 7(4):189-97.
8. Alves R, Grimalt R. A Review of Platelet-Rich Plasma: History, Biology, Mechanism of Action, and Classification. Skin Appendage Disord 2018; 4(1):18-24.
9. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, et al. Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part II: Platelet-related biologic features. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006; 101(3):e45-50.
10. Choukroun J, Diss A, Simonpieri A, Girard MO, Schoeffler C, Dohan SL, et al. Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part V: Histologic evaluations of PRF effects on bone allograft maturation in sinus lift. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006; 101(3):299-303.
11. O’Connell SM. Safety Issues Associated With Platelet-Rich Fibrin Method. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007; 103(5):587.
12. Dohan DM, Corso M, Charrier JB. Cytotoxicity analyses of Choukroun platelet-rich fibrin (PRF) on a wide range of human cells: The answer to a commercial controversy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007; 103(5):587-93.
13. Choukroun J, Diss A, Simonpieri A, Girard MO, Schoeffler C, Dohan SL, et al. Platelet-rich fibrin (PRF): A secondgeneration platelet concentrate. Part IV: Clinical effects on tissue healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006; 101(3):e56-60.
14. Arribillaga L, Dotor J, Basagoiti M, Riezu-Boj J, BorrásCuesta F, Lasarte J, et al. Therapeutic effect of a peptide inhibitor of TGF-β on pulmonary fibrosis. Cytokine. 2011; 53(3):327-33.
15. He Y, Chen J, Huang Y, Pan Q, Nie M. Local Application of Platelet-Rich Fibrin During Lower Third Molar Extraction Improves Treatment Outcomes. J Oral Maxillofac Surg 2017; 75(12):2497-506.
16. Lucarelli E, Beccheroni A, Donati D, Sangiorgi L, Cenacchi A, Vento AM, et al. Platelet-derived growth factors enhance proliferation of human stromal stem cells. Biomaterials 2003; 24(18):3095-100.
17. Butt AJ, Firth SM, Baxter RC. The IGF axis and programmed cell death. Immunol Cell Biol 1999; 77(3):256-62.
18. Winkler R, Pasleau F, Boussif N, Hodzic D. The IGF system: summary and recent data. Rev Med Liege. 2000; 55(7):725-39.
19. Miron RJ, Fujioka-Kobayashi M, Hernandez M, Kandalam U, Zhang Y, Ghanaati S, et al. Injectable platelet rich fibrin (i-PRF): opportunities in regenerative dentistry? Clin Oral Invest 2017; 21(8):2619-27.
20. Miron RJ, Zhang Y. Autologous Liquid Platelet Rich Fibrin: a novel drug delivery system. Acta Biomater 2018; 15(75):35-51.
21. Guyton AC, Hall JE. Textbook of Medical Physilogy. 11. ed. Philadelphia: Saunders; 2006.
22. Eriksen E, Kassem M, Langdahl B. Growth hormone, insulin-like growth factors and bone remodelling. Eur J Clin Invest 1996; 26(7):525-34.
23. Varkey M, Gittens SA, Uludag H. Growth factor delivery for bone tissue repair: an update. Expert Opin Drug Deliv 2005; 1(1):19-36.
24. Simpson A, Mills L, Noble B. The role of growth factors and related agents in accelerating fracture healing. J Bone Joint Surg Br 2006; 88(6):701-5.
25. Calvo-Guirado J, Mate-Sanchez J, Delgado-Ruiz R, RamirezFernández M, Cutando-Soriano A, Peña M. Effects of growth hormone on initial bone formation around dental implants: a dog study. Clin Oral Implants Res 2011; 22(6):587-93.
26. Bail H, Klein P, Kolbeck S, Krummrey G, Weiler A, Schmidmaier G, et al. Systemic application of growth hormone enhances the early healing phase of osteochondral defects – a preliminary study in micropigs. Bone 2003; 32(5):457-67.
27. Tresguerres IF, Blanco L, Clemente C, Tresguerres JA. Effects of local administration of growth hormone in peri-implant bone: an experimental study with implants in rabbit tibiae. Int J Oral Maxillofac Implants 2003; 18(6):807-11.
28. Pagnoncelli R, da Gerzson A, Camilotti R, Jasper J, Böing F. Hormônio do crescimento humano e a perspectiva futura em Odontologia. Rev Fac Odontol Univ Passo Fundo 2014; 19(3):379-83.
29. Clark R. Fibrin and Wound Healing. Ann NY Acad Sci 2001; 936(1):355-67.
30. Shah R, Gowda T, Thomas R, Kumar T, Mehta D. Biological activation of bone grafts using injectable platelet-rich fibrin. J Prosthet Dent 2018; 121(3):391-3
31. Fujioka-Kobayashi M, Miron RJ, Hernandez M, Kandalam U, Zhang Y, Choukroun J. Optimized Platelet-Rich Fibrin With the Low-Speed Concept: Growth Factor Release, Biocompatibility, and Cellular Response. J Periodontol 2017; 88(1):112-21.
32. Guicheux J, Gauthier O, Aguado E, Pilet P, Couillaud S, Jegou D, et al. Human Growth Hormone Locally Released in Bone Sites by Calcium-Phosphate Biomaterial Stimulates Ceramic Bone Substitution Without Systemic Effects: A Rabbit Study. J Bone Miner Res 1998; 13(4):739-48.
33. Gómez-Moreno G, Cutando A, Arana C, Worf C, Guardia J, Muñoz F, et al. The effects of growth hormone on the initial bone formation around implants. Int J Oral Maxillofac Implants 2009; 24(6):1068-73.
34. Tresguerres IF, Clemente C, Donado M, Gómez-Pellico L, Blanco L, Alobera M, et al. Local administration of growth hormone enhances periimplant bone reaction in an osteoporotic rabbit model. Clin Oral Implants Res 2002; 13(6):631-6.
35. Webster R, Xie R, Didier E, Finn R, Finnessy J, Edgington A, et al. PEGylation of somatropin (recombinant human growth hormone): Impact on its clearance in humans. Xenobiotica 2008; 38(10):1340-51.
36. Mullis PE, Pal RB, Matthews DR, Hindmarsh PC, Phillips PE, Dunger DB. Half-life of exogenous growth hormone following suppression of endogenous growth hormone secretion with somatostatin in type I (insulin-dependent) diabetes mellitus. Clin Endocrinol 1992; 36(3):255-63.
37. Lanzi R, Andreotti A, Caumo A, Manzoni M, Losa M, Malighetti M, et al. Assessment of growth hormone (GH) plasma clearance rate, half-life, and volume of distribution in acromegalic patients: the combined GH-octreotide infusion. J Clin Endocrinol Metabolism 1995; 80(11):3279-83.
38. Gerzson A, Machado D, Marinovic D, Pagnoncelli R. Assessment of Adhesion and Proliferation of Bone Marrow Mesenchymal Stem Cells in Polymer Matrices with rhGH. Int J Oral Maxillofac Implant. 2017; 32(3):e183-9.
39. Yang H, La WG, Cho YM, Shin W, Yeo GD, Kim BS. Comparison between heparin-conjugated fibrin and collagen sponge as bone morphogenetic protein-2 carriers for bone regeneration. Exp Mol Medicine 2012; 44(5):350-5.
40. Polak D, Clemer-Shamai N, Shapira L. Incorporating antibiotics into platelet-rich fibrin: A novel antibiotics slow-release biological device. J Clin Periodontol 2019; 46(2):241-7.
41. Hindmarsh PC, Dattani MT. Use of growth hormone in children. Nat Clin Pract Endoc 2006; 2(5):260-8.
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Use of the growth hormone associated with injectable platelet-rich fibrin (I-PRF). (2019). Revista Da Faculdade De Odontologia - UPF, 24(2), 309-315. https://doi.org/10.5335/rfo.v24i2.10460
