Occurrence of non-melanoma labial squamous cell carcinoma in chronic users of hydrochlorothiazide
DOI:
https://doi.org/10.5335/rfo.v27i1.14222Keywords:
Photosensitizing agents. Hydrochlorothiazide. Mouth Cancer. Squamous Cell Carcinoma. Anti-Hypertensives.Abstract
Introduction: Several authors have developed studies about a potential association between the etiocarcinogenesis of non-melanocytic lip squamous cell carcinoma (NMSCC) and the chronic use of hydrochlorothiazide (HCTZ). Objective: The current study aimed to investigate the relation between the diuretic HCTZ and the risk of lip NMSCC. Methods: A literature review was carried out in the LILACS, PUBMED/MEDLINE and CAPES Periodical databases, which included articles in English, Portuguese and French, published between 2017 and 2022. Sixty documents were collected and, among these, 30 were selected to compose the sample in the study. Results: There was evidence of a relationship between the use of HCTZ and the occurrence of MSCC with a cumulative dose relationship due to changes caused by the drug, however, because of the heterogeneity of methodological designs and concentration of studies in similar populations, there are limitations regarding the reliability of this information. Conclusion: A disproportion between the occurrence and relevance of the NMSCC and the current scientific production was identified, demonstrating the need for studies with standardized methodologies that cover different demographic socioeconomic specificities.
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References
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19. Lee H, Shin J, Kim G, Park S, Ihm S, Kim H, et al. Korean Society of Hypertension Guidelines for the management of hypertension: part II-diagnosis and treatment of hypertension. Clin Exp Hypertens. 2019;25:20.
20. Kreutz R, Algharably EAH, Douros, A. Reviewing the effects of thiazide and thiazide-like diuretics as photosensitizing drugs on the risk of skin cancer. J Hypertens. 2019;37(10):1950-1958.
21. Su KA, Habel LA, Achacoso NS, Friedman GD, Agasri MM. Photosensitizing antihypertensive drug use and risk of cutaneous squamous cell carcinoma. Br J Dermatol. 2018;179(5):1088-1094.
22. Montgomery S e Scott W. Photosensitizing Drug Reactions. Clin Dermatol. 2022 Jan-Feb;40(1):57-63.
23. Mehlan J, Ueberschaar J, Hagenström K, Garbe C, Spitzer MS, Druchkiv V, Schuettauf F. The use of HCT and/or ACE inhibitors significantly increases the risk of non-melanotic skin cancer in the periocular region. Graefes Arch Clin Exp Ophthalmol. 2022;260(8):2745-2751.
24. Rouette J, Yin H, Pottegård A, Nirantharakumar K, Azoulay L. Use of Hydrochlorothiazide and Risk of Melanoma and Nonmelanoma Skin Cancer. Drug Saf. 2021;44(2):245-254.
25. Schneider R, Reinau D, Stoffel S, Jick SS, Meier CR, Spoendlin J. Risk of skin cancer in new users of thiazides and thiazide-like diuretics: a cohort study using an active comparator group. Br J Dermatol. 2021;185(2):343-352.
26. Eworuke E, Haug N, Bradley M, Cosgrove A, Zhang T, Dee EC, et al. Risk of Nonmelanoma Skin Cancer in Association With Use of Hydrochlorothiazide-Containing Products in the United States. JNCI Cancer Spectr. 2021;5(2).
27. Pottegard A, Hallas J, Olesen M, Svendsen MT, Habel LA, Friedman GD, Friis S. Hydrochlorithiazide use is strongly associated with risk of lip cancer. J Intern Med. 2017;282(4):322-331.
28. Morales DR, Pacurariu A, Slattery J, Kurz X. Association between hydrochlorothiazide exposure and different incident skin, lip and oral cavity cancers. Br J Clin Pharmacol. 2020;86(7):1336-1345.
29. Park E, Lee Y, Jue MS. Hydrochlorothiazide use and the risk of skin cancer in patients with hypertensive disorder: a nationwide retrospective cohort study from Korea. Korean J Intern Med. 2020;35(4):917-928.
30. Pottegard A, Pedersen SA, Schmidt SAJ, Lee CN, Hsu CK, Liao TC, et al. Hydrochlorithiazide use and skin cancer risk: a Taiwanese national case-control study. Br J Cancer. 2019;121(11):973-978.
2. Garrido PM e Costa JB. Terapêutica com hidroclorotiazida e risco de cancro cutâneo não melanoma: revisão da literatura. Rev Port Cardiol. 2019;39(3):163-170.
3. Korzeniowska K, Cieślewicz A, Chmara E, Jabłecka A, Pawlaczyk M. Photosensitivity reactions in the elderly population: questionnaire-based survey and literature review. Ther Clin Risk Manag. 2019;15:1111-1119.
4. Llamas-Molina JM, Navarro-Triviño FJ, Ruiz-Villaverde R. What Dermatologists Should Know About Thiazides. Actas Dermosifiliogr. 2022;113(5):498-504.
5. Bendinelli B, Masala G, Garamella G, Palli D, Caini S. Do thiazide diuretics increase the risk of skin cancer? A critical review of the scientific evidence and updated meta-analysis. Curr Cardiol Rep. 2019;21(9):92.
6. A.C. Camargo Cancer Center. Pele Não Melanoma. Disponível em: https://www.accamargo.org.br/sobre-o-cancer/tipos-de-cancer/pele-nao-melanoma. Acesso em: 05, jul, 2022.
7. Andrade KVF e Souza AM. Prevalência de interações medicamentosas potenciais em indivíduos hipertensos acompanhados na estratégia de saúde da família. J Biol Sci. 2018;6(4):405-411.
8. Lee SM, Kim K, Yoon J, Park SK, Moon S, Lee SE, et al. Association between hydrochlorothiazide use and risk of non-melanoma skin cancer: cohort study of the common data model in the Asian population. J Clin Med. 2020;9(9):2910.
9. Shin D, Lee ES, Kim J, Guerra L, Naik D, Prida X. Association Between the Use of Thiazide Diuretics and the Risk of Skin Cancers: A Meta-Analysis of Observational Studies. J Clin Med Res. 2019;11(4):247-255.
10. Warszawik-Hendzel O, Olszewska M, Rakowska A, Sikora M, Hendzel P, Rudnicka L. Cardiovascular Drug Use and Risk of Actinic Keratosis: A Case-Control Study. Dermatol Ther (Heidelb). 2020;10(4):735-743.
11. Bigagli E, Cinci L, D’ambrosio M, Nardini P, Portelli F, Colucci R, et al. Hydrochlorothiazide Use and Risk of Nonmelanoma Skin Cancers: A Biological Plausibility Study. Oxid Med Cell Longev. 2021;2021:6655542.
12. O’neill B, Moe S, Korownyk C. Hydrochlorothiazide and squamous cell carcinoma. Can Fam Physician. 2020;66(2):116-116.
13. Drucker AM, Hollestein L, Na Y, Weinstock MA, Li WQ, Abdel Qadir HA, et al. Association between antihypertensive medications and risk of skin cancer in people older than 65 years: a population-based study. CMAJ. 2021;193(15):508-516.
14. Perdersen SA, Gaist D, Schimidt SAJ, Hölmich LR, Friis S, Pottegård A. Hydrochlorothiazide use and risk of nonmelanoma skin cancer: A nationwide case-control study from Denmark. J Am Acad Dermatol. 2018;78(4):673-681.
15. Borges JES, Camelier AA, Oliveira LVF, Brandão GS Qualidade de vida de idosos hipertensos e diabéticos da comunidade: um estudo observacional. Rev Pesqui Fisioter. 2019;9(1):74-84.
16. Dias JRP, Andrade RL, Fernandes ANM, Laurindo BM, Fonseca ERS. Análise do perfil clínico-epidemiológico dos idosos portadores de hipertensão arterial sistêmica nas microáreas 4, 6 e 7 da USF tenoné. BJHR. 2019;2(1):2-41.
17. Kim H, Ihm S, Kim G, Kim J, Kim K, Lee H, et al. Korean Society of Hypertension guidelines for the management of hypertension: part I-epidemiology of hypertension. Clin Exp Hypertens. 2019;25:1-16 – A.
18. Kim H, Ihm S, Kim G, Kim J, Kim K, Lee H, et al. Korean Society of Hypertension guidelines for the management of hypertension: part III-hypertension in special situations. Clin Exp Hypertens. 2019;25:1-16 – B.
19. Lee H, Shin J, Kim G, Park S, Ihm S, Kim H, et al. Korean Society of Hypertension Guidelines for the management of hypertension: part II-diagnosis and treatment of hypertension. Clin Exp Hypertens. 2019;25:20.
20. Kreutz R, Algharably EAH, Douros, A. Reviewing the effects of thiazide and thiazide-like diuretics as photosensitizing drugs on the risk of skin cancer. J Hypertens. 2019;37(10):1950-1958.
21. Su KA, Habel LA, Achacoso NS, Friedman GD, Agasri MM. Photosensitizing antihypertensive drug use and risk of cutaneous squamous cell carcinoma. Br J Dermatol. 2018;179(5):1088-1094.
22. Montgomery S e Scott W. Photosensitizing Drug Reactions. Clin Dermatol. 2022 Jan-Feb;40(1):57-63.
23. Mehlan J, Ueberschaar J, Hagenström K, Garbe C, Spitzer MS, Druchkiv V, Schuettauf F. The use of HCT and/or ACE inhibitors significantly increases the risk of non-melanotic skin cancer in the periocular region. Graefes Arch Clin Exp Ophthalmol. 2022;260(8):2745-2751.
24. Rouette J, Yin H, Pottegård A, Nirantharakumar K, Azoulay L. Use of Hydrochlorothiazide and Risk of Melanoma and Nonmelanoma Skin Cancer. Drug Saf. 2021;44(2):245-254.
25. Schneider R, Reinau D, Stoffel S, Jick SS, Meier CR, Spoendlin J. Risk of skin cancer in new users of thiazides and thiazide-like diuretics: a cohort study using an active comparator group. Br J Dermatol. 2021;185(2):343-352.
26. Eworuke E, Haug N, Bradley M, Cosgrove A, Zhang T, Dee EC, et al. Risk of Nonmelanoma Skin Cancer in Association With Use of Hydrochlorothiazide-Containing Products in the United States. JNCI Cancer Spectr. 2021;5(2).
27. Pottegard A, Hallas J, Olesen M, Svendsen MT, Habel LA, Friedman GD, Friis S. Hydrochlorithiazide use is strongly associated with risk of lip cancer. J Intern Med. 2017;282(4):322-331.
28. Morales DR, Pacurariu A, Slattery J, Kurz X. Association between hydrochlorothiazide exposure and different incident skin, lip and oral cavity cancers. Br J Clin Pharmacol. 2020;86(7):1336-1345.
29. Park E, Lee Y, Jue MS. Hydrochlorothiazide use and the risk of skin cancer in patients with hypertensive disorder: a nationwide retrospective cohort study from Korea. Korean J Intern Med. 2020;35(4):917-928.
30. Pottegard A, Pedersen SA, Schmidt SAJ, Lee CN, Hsu CK, Liao TC, et al. Hydrochlorithiazide use and skin cancer risk: a Taiwanese national case-control study. Br J Cancer. 2019;121(11):973-978.
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2023-11-06
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Occurrence of non-melanoma labial squamous cell carcinoma in chronic users of hydrochlorothiazide. (2023). Revista Da Faculdade De Odontologia - UPF, 27(1). https://doi.org/10.5335/rfo.v27i1.14222
