Hemorrhagic bullous angina: clinical, histopathological characteristics, diagnosis and therapeutic strategies
DOI:
https://doi.org/10.5335/rfo.v28i1.15484Keywords:
Hemorrhagic bullous angina, Benign hemorrhagic bullous stomatitis, Oral pathologyAbstract
Introduction: Hemorrhagic bullous angina (ABH) is a rare, benign and generally asymptomatic condition, characterized by the sudden appearance of blisters filled with blood on the mucous surfaces of the oral cavity and oropharynx. Objective: This work aims to provide a comprehensive analysis of the clinical, etiological and histopathological characteristics of hemorrhagic bullous angina, in addition to addressing diagnostic methods and treatment options. Materials and methods: A search was carried out for scientific articles published from 2010 to 2023, in the Scientific Electronic Library Online (SciELO), US National Library of Medicine (PubMed) and ScienceDirect databases. Articles were collected in English and Portuguese using the keywords "hemorrhagic bullous angina", "benign hemorrhagic bullous stomatitis", "hemorrhagic bullous angina" and "benign hemorrhagic bullous stomatitis". Conclusion: ABH is scarcely documented in the literature, with many data missing or underreported. Although it is a benign condition with rapid spontaneous evolution, the diagnostic procedure must be rigorous to rule out other possible lesions.
Downloads
References
Silva-Cunha JL, Cavalcante IL, Barros CC, Felix FA, Venturi LB, Rolim LS, et al. Angina bullosa haemorrhagica: A 14-year multi-institutional retrospective study from Brazil and literature review. Medicina Oral Patología Oral y Cirugia Bucal. 2022; e35-41.
Julieta Ruíz Beguerie, Silvina González. Angina bullosa hemorrhagica: report of 11 cases. Dermatology Reports [Internet]. 2014;6(1). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224003/
Rodrigues S, Albrechete M, Rafael, Azis Arruda Chagury, Lorenzetti F. Hemorrhagic Bullous Angina: A Case Report and Review of the Literature. Türk otolarengoloji arÅŸivi [Internet]. 2016;54(3):134-137. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5782964/
Lai J, Irene. Angina bullosa haemorrhagica: Accelerated healing following kiwi consumption. JAAD Case Reports [Internet]. 2023; 38:86-88. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362006/
Rother ET. Systematic literature review X narrative review. Acta Paulista de Enfermagem [Internet]. 2007;20(2):v–vi. Available from: http://www.scielo.br/scielo.php?pid=S0103-21002007000200001&script=sci_arttext&tlng=en
Martins CAM, Gomes FV, Freddo AL, Heitz C, Moresco FC, Silveira JOL da. Angina bullosa haemorrhagica (ABH): diagnosis and treatment. RFO UPF [Internet]. 2012;17(3):347-351. Available from: http://revodonto.bvsalud.org/scielo.php?script=sci_abstract&pid=S1413-40122012000300018&lng=en&nrm=iso&tlng=en
Mortazavi H, Sadeghian A, Hazrati P, Heydari MH, Madihi S. Oral hemorrhagic blister and its possible related factors: Analyzes of reported cases in the literature. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology [Internet]. 2023;35(4):358-367. Available from: https://www.sciencedirect.com/science/article/abs/pii/S2212555823000054
Okobi OE, Evbayekha EO, Ebili U, Ogbonna UO, Ogundiran F, Ebong IL. Angina Bullosa Hemorrhagica: A Rare and Interesting Presentation. Cureus. 2022.
Zhao P, Noland MMB, Guffey DJ. Recurrent hemorrhagic bullae of the oral mucosa. JAAD Case Reports [Internet]. 2023; 34:48-51. Available from: https://www.sciencedirect.com/science/article/pii/S2352512623000589?via%3Dihub
Ordioni U, Hadj Saïd M, Thiery G, Campana F, Catherine JH., Lan R. Angina bullosa haemorrhagica: a systematic review and proposal for diagnostic criteria. International Journal of Oral and Maxillofacial Surgery. 2019;48(1):28-39.
Shoor H, Mutalik S, Pai KM. Angina bullosa haemorrhagica. Case Reports. 2013;2013(dec11 3):bcr2013200352.
Salih Levent Çınar, Demet Kartal, Özlem Canöz, Murat Borlu, Ayten FerahbaÅŸ. Case Report: A rare cause of oral bullae: Angina bullosa hemorrhagica. F1000Research [Internet]. 2017; 6:1974. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728194/
Yorulmaz A, Yalcin B. Is inhaled glucocorticoids the only culprit in angina bullosa hemorrhagica? Indian Journal of Pharmacology. 2018;50(2):91.
Nayak P, Gupta S, Vivek Kumar Pathak, Kalra R. Angina Bullosa Haemorrhagica in COVID 19: A Diagnostic Conundrum. Case Report and Review of Literature. Indian Journal of Otolaryngology and Head & Neck Surgery [Internet]. 2023;75(3):2650-2656. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979882/
Supekar BB, Sawatkar GU, Wankhade VH. Angina bullosa hemorrhagica. Indian Dermatology Online Journal [Internet]. 2019;10(1):89. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362741/
Balighi K, Daneshpazhooh M, Aghazadeh N, Rahbar Z, Mahmoudi H, Sadjadi A. Angina bullosa haemorrhagica-like lesions in pemphigus vulgaris. The Australasian Journal of Dermatology [Internet]. 2019;60(2):e105-108. Available from: https://pubmed.ncbi.nlm.nih.gov/30215869/
Alotaiby F, Al-Homaid M, Islam MN, Bhattacharyya I, Alramadhan SA. Angina bullosa hemorrhagica: report of two cases. Quintessence International (Berlin, Germany: 1985) [Internet]. 2022;53(2):180-185. Available from: https://pubmed.ncbi.nlm.nih.gov/34709773/
Alberdi-Navarro J, García-García A, Cardona-Tortajada F, Gainza-Cirauqui M, Aguirre-Urizar J. Angina bullosa hemorrhagica, an uncommon oral disorder. Report of 4 cases. Journal of Clinical and Experimental Dentistry. 2020; e509-513.
Navab R, Jangamareddy VRY, Navab R, Jangamareddy VRY. Angina Bullosa Hemorrhagica of the Oral Mucosa: A Case Report. Cureus [Internet]. 2022;14(5). Available from: https://www.cureus.com/articles/95774-angina-bullosa-hemorrhagica-of-the-oral-mucosa-a-case-report#.
Yadav A, Yadav P, Chander R, Sharma A. Giant angina bullosa haemorrhagica. Indian Dermatology Online Journal. 2020;11(6):1036.
Patigaroo SA, Dar NH, Thinles T, Islam M ul. Multiple angina bullosa hemorrhagica—A case report. International Journal of Pediatric Otorhinolaryngology Extra [Internet]. 2014;9(3):125-127. Available from: https://www.sciencedirect.com/science/article/abs/pii/S1871404814000331
Downloads
Published
Issue
Section
License
Copyright (c) 2024 Revista da Faculdade de Odontologia - UPF

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

This work is licensed under aCreative Commons Atribuição-NãoComercial-SemDerivações 4.0 Internacional.
						