Application of ascorbic acid in provoked ulceration on tongue of guinea pig (Cevie porcellus) - histologicel evolution

Abstract

The purpose of the present work was to histologically verify the capacity of tissue repair in response to topical application of ascorbic acid (C vitamin) in pro- voked ulceration on the central dorsum of the tongue, in Cavia porcellus (guinea pig.). Twenty (20) animals were used in the experiment, divided into Control group (10 animals) and experi- mental group (10 animals) which received ascorbic acid topically. Each group was sacrificed at the 3th, 5th, 7t h, and 14th day of the experiment and the specimens were histologically evaluated af- ter the surgery. The histological exam of the specimens showed that in the beginning of the tis- sular repair is qualitatively and quantitatively improved with the topical application ofascorbic acid application in both of the groups. A fast decrease of inflammatory answer was observed, as well as an intense transformation of the cells and their products. On the other hand, on the final stages of the reparation process, the topi- cally applied ascorbic acid on the ulceration made difficult or de- layed the tis sular reparation. Key words: tissue repair, ascorbic acid, tissularregeneration, cicatri- zation.