Ozone as a remineralizing agent in the treatment of caries lesions: a literature review
DOI:
https://doi.org/10.5335/rfo.v30i1.16471Keywords:
ozônio, ozonioterapia, cárie dentária, remineralização dentária, odontologiaAbstract
Introduction: Dental caries is one of the most prevalent diseases in the world, and the possibilities for its treatment are constantly being studied and evolving. Ozone has been presented as a promising possibility for treating caries lesions due to its ability to remineralize dental tissue. However, it is necessary to further investigate the effectiveness of this technique for its clinical use. Objective: to carry out a review of scientific literature in order to analyze, compile and present data related to ozone as a remineralizing agent in the treatment of caries lesions. Method: the search for materials was conducted in the PubMed, Bireme and SciELO databases, including articles published from 2011 to 2024, in Portuguese and English. The initial search resulted in 89 articles. Of these, 77 were excluded because they did not meet the established inclusion criteria. In total, 12 articles were selected for detailed analysis. Literature review: the research analyzed showed divergences in relation to the results obtained: some studies identified the remineralizing action of ozone, either alone or in combination with other agents and treatments, while other studies indicated that ozone had lower efficacy compared to others remineralizing agents. Conclusion It is possible to highlight that ozone has potential as a remineralizing agent in the treatment of caries lesions, and can serve as an alternative to conventional techniques. However, more studies are needed to ensure its effectiveness.
Keywords: ozone; ozone therapy; tooth decay; dental remineralization; dentistry.
Downloads
References
World Health Organization. Sugar and dental caries. Disponível em: https://www.who.int/news-room/fact-sheets/detail/sugars-and-dental-caries. Accessed: 11 Jul 2024.
Silva GS, Cunha TCR, Guimarães TGFA. Uso de flúor como prevenção e tratamento para a cárie: revisão de literatura. Res Soc Dev. 2022 Aug 1;11(10):e289111032848.
Sousa GP, Lima CCB, Braga MM, Moura LFAD, Lima MDM, Moura MS. Early childhood caries management using fluoride varnish and neutral fluoride gel: a randomized clinical trial. Braz Oral Res. 2022 Jul 11;36:e099.
Mainente MP, Naves PA, de Campos PH, Rodrigues MC, Diniz MB, Zaroni WCS, et al. Inhibition of incipient caries lesion progression by different fluoridated varnishes. Braz Dent J. 2024;35:e24-5616.
Silva AM, Guimarães ARD, Costa HSO. O uso do diamino fluoreto de prata no controle de lesões cariosas: uma revisão integrativa. J Dent Pub H. 2018;9(4):311-24.
Ballikaya E, Ünverdi GE, Cehreli ZC. Management of initial carious lesions of hypomineralized molars (MIH) with silver diamine fluoride or silver-modified atraumatic restorative treatment (SMART): 1-year results of a prospective, randomized clinical trial. Clin Oral Investig. 2022;26(2):2197-2205.
Zheng FM, Yan IG, Duangthip D, Lo ECM, Gao SS, Chu CH. Caries prevention using silver diamine fluoride: a 12-month clinical trial. Int Dent J. 2022;73(5):2197-2205.
Ruff RR, Barry-Godín T, Niederman R. Effect of silver diamine fluoride on caries arrest and prevention the cariedaway school-based randomized clinical trial. JAMA Netw Open. 2023;6(2):e2255458.
Samuel SR, Dorai S, Khatri SG, Patil ST. Effect of ozone to remineralize initial enamel caries: in situ study. Clin Oral Investig. 2016;20(5):1109-13.
Grocholewicz K, Matkowska-Cichocka G, Makowiecki P, Droździk A, Ey-Chmielewska H, Dziewulska A, et al. Effect of nano-hydroxyapatite and ozone on approximal initial caries: a randomized clinical trial. Sci Rep. 2020;10(1):11192.
Atabek D, Oztas N. Effectiveness of ozone with or without the additional use of remineralizing solution on non-cavitated fissure carious lesions in permanent molars. Eur J Dent. 2011;5(4):393-9.
Duggal MS, Nikolopoulou A, Tahmasebi JF. The additional effect of ozone in combination with adjunct remineralization products on inhibition of demineralisation of the dental hard tissues in situ. J Dent. 2012;40(11):934-40.
Tahmasebi JF, Chrysaï¬ N, Duggal MS. The effect of ozone on progression or regression of artificial caries-like enamel lesions in vitro. J Dent. 2013;42(2):167-74.
Yazıcıoğlu O, Ulukapi H. The investigation of non-invasive techniques for treating early approximal carious lesions: an in vivo study. Int Dent J. 2014;64(1):1-11.
Unal M, Oztas N. Remineralization capacity of three fissure sealants with and without gaseous ozone on non-cavitated incipient pit and fissure caries. J Clin Pediatr Dent. 2015;39(4):364-70.
Floare AD, Focht D, Hajdu AI, Talpos ICN, Bălean OI, Muntean CV, et al. Ozone and microstructural morphological changes of tooth enamel. Rom J Morphol Embryol. 2022;63(3):539-44.
Jena D, Manas A, Venkateswararao CH, Salama MT, Ismail MS, Basha SR. Comparative evaluation of efficacy of bioactive glass, tricalcium phosphate, and ozone remineralizing agents on artificial carious lesion. J Pharm Bioallied Sci. 2022;14(1):S959-S961.
Kade KK, Chaudhary S, Shah R, Patil S, Patel A, Kamble A. Comparative evaluation of the remineralization potential of fluoride-containing toothpaste, honey ginger paste and ozone: an in vitro study. Int J Clin Pediatr Dent. 2022;15(5):541-8.
Alessa N, Shah SA, Bhardwaj R, Ismail PMS, Mahabob MN, Babaji P, et al. Assessment of efficiency of bioactive glass, self-assembling peptide, and ozone remineralising agents on artificial carious lesion. Pesqui Bras Odontopediatria Clín Integr. 2024;24(11):e220123.
Shah SA, Sharma M, Ismail PMS, Babaji P, Mohammed A, Malik B, et al. Evaluation of remineralizing capacity of tricalcium phosphate, nano-hydroxyapatite and ozone remineralizing agents on the artificial carious lesion. Indian J Dent Res. 2024;35(1):84-7.
Walsh T, Worthington HV, Glenny A, Appelbe P, Marinho VC, Shi X. Fluoride toothpastes of different concentrations for preventing dental caries in children and adolescents. Cochrane Database Syst Rev. 2010;(1):1-221.
Cury JA, Tenuta LMA. Evidence-based recommendation on toothpaste use. Braz Oral Res. 2014;28(SPE):1-7.
Conselho Federal de Odontologia. Resolução n.166, de 24 de novembro de 2015. Diário Oficial da União. Brasília, seção 1, p. 95, 08 dez 2015.
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
This work is licensed under aCreative Commons Atribuição-NãoComercial-SemDerivações 4.0 Internacional.
