Metastasis of a renal tumor in the tongue: case report and literature update

Authors

  • GABRIEL MACIEL UFSM
  • Carlos Felipe Santos Andrade UFSM
  • Eva Castro Torriani
  • Cláudio Dellinghausen Silveira
  • Kívia Linhares Ferrazzo
  • Cristiane Cademartori Danesi

DOI:

https://doi.org/10.5335/rfo.v29i1.15654

Keywords:

Carcinoma de Células Renais, Metástase Neoplásica, Diagnóstico Diferencial, Patologia oral

Abstract

Aim: To report a rare case of metastasis of renal cell carcinoma (RCC) in the tongue and highlight relevant aspects for the dentist. Materials and Methods: Caucasian male patient, 60 years old, with a history of RCC with bone metastasis. Clinically, a nodular lesion was observed on the left side of the tongue, measuring 2.3 centimeters in its largest diameter, non-ulcerated, asymptomatic, and also a nodular lesion on the scalp. The patient was referred to a head and neck surgeon and an excisional biopsy was performed. Results: Histopathological examination confirmed the metastatic nature of the lesions on the tongue and scalp, originating from a RCC. Conclusion: Although the occurrence of metastasis in the tongue is rare, it is essential that the dentist is aware of this possibility, especially when dealing with patients with a history of malignant tumor.

Downloads

Download data is not yet available.

References

Retsas S. Cancer and the arts: metastasis-as perceived through the ages. ESMO Open. 2017 Jul 29;2(3):e000226.

Gerstberger S, Jiang Q, Ganesh K. Metastasis. Cell. 2023 Apr 13;186(8):1564-1579.

Khan SU, Fatima K, Malik F, Kalkavan H, Wani A. Cancer metastasis: Molecular mechanisms and clinical perspectives. Pharmacol Ther. 2023;250:108522.

Allon I, Pessing A, Kaplan I, Allon DM, Hirshberg A. Metastatic Tumors to the Gingiva and the Presence of Teeth as a Contributing Factor: A Literature Analysis. J.Periodontol. 2014;85(1):132-9.

Aldin A, Besiroglu B, Adams A, Monsef I, Piechotta V, Tomlinson E, Hornbach C, Dressen N, Goldkuhle M, Maisch P, Dahm P, Heidenreich A, Skoetz N. Firstâ€line therapy for adults with advanced renal cell carcinoma: a systematic review and network metaâ€analysis. Cochrane Database of Systematic Reviews 2023, Issue 5.

Kase AM, George DJ, Ramalingam S. Clear Cell Renal Cell Carcinoma: From Biology to Treatment. Cancers (Basel). 2023;15(3):665.

Azam F, Abubakerr M, Gollins S. Tongue metastasis as an initial presentation of renal cell carcinoma: A case reporte and literature review. J Med Case Rep. 2008; 2:1-5.

Hirshberg A, Berger R, Allon I, Kaplan I. Metastatic Tumors to the Jaws and Mouth. Head Neck Pathol. 2014;8(4):463-74.

Kirschick LB, Schuch LF, Cademartori MG, Vasconcelos ACU. Metastasis to the oral and maxillofacial region: A systematic review. Oral Dis. 2022;28(1):23-32.

AltuntaÅŸ O, Petekkaya İ, Süslü N, Güllü İ. Renal cell carcinoma metastatic to the tongue: a case report and review of the literature. J Oral Maxillofac Surg. 2015;73(6):1227-1230.

Torres-Carranza E, Garcia-Perla A, Infante-Cossio P, Belmonte-Caro R, Loizaga-Iriondo JM, Gutierrez-Perez JL. Airway obstruction due to metastatic renal cell carcinoma to the tongue. Oral Surgery, Oral Med Oral Pathol Oral Endodontology. 2006;101(3):76-8.

Raiss H, Duplomb S, Tartas S, Layachi M, Errihani H. Lingual metastasis as an initial presentation of renal cell carcinoma: A case report. J Med Case Rep. 2017;11(1):5-11.

Siegel, R.L.; Miller, K.D.; Fuchs, H.E.; Jemal, A. Cancer Statistics, 2021. CA Cancer J. Clin. 2021; 71, 7–33.

Van der Waal RIF, Buter J, van der Waal I. Oral metastases: Report of 24 cases. Br J Oral Maxillofac Surg. 2003;41(1):3-6.

Jham BC, Salama AR, McClure AS, Ord RA. Metastatic Tumors to the Oral Cavity: A Clinical Study of 18 Cases. Head Neck Pathol. 2011;5(4):355-8.

Lieder A, Guenzel T, Lebentrau S, Schneider C, Franzen A. Diagnostic relevance of metastatic renal cell carcinoma in the head and neck: An evaluation of 22 cases in 671 patients. Int Braz J Urol. 2017;43(2):202-8.

Servato JP, De Paulo LFB, De Faria PR, Cardoso SV, Loyola AM. Metastatic tumours to the head and neck: Retrospective analysis from a Brazilian Tertiary referrel centre. Int J Oral Maxillofac Surg [Internet]. 2013;42(11):139-6.

Nisi M, Izzetti R, Graziani F, Gabriele M. Renal Cell Carcinoma Metastases to the Oral Cavity: Report of 2 Cases and Review of Literature. J Oral Maxillofac Surg [Internet]. 2020;78(9):1557-71.

Aguirre A, Rinaggio J, Diaz-Ordaz E. Lingual metastasis of renal cell carcinoma. J Oral Maxillofac Surg. 1996;54(3):344-7.

Ghazali N, Davis C, Barrett AW, Tighe JV. Bilateral Asynchronous Renal Cell Carcinoma with Metastatic Involvement of the Tongue. Case Rep Pathol. 2012;1-4.

Christensen, M.; Hannan, R. The Emerging Role of Radiation Therapy in Renal Cell Carcinoma. Cancers 2022;14, 4693.

Danic P, Danic D, Macan D. Tongue metastasis as an initial presentation of renal cell carcinoma. Med Glas. 2018;15(1):52-8.

Shimono H, Hirai H, Oikawa Y, Mochizuki Y, Kuroshima T, Tomioka H, et al. Metastatic tumors in the oral region: a retrospective chart review of clinical characteristics and prognosis. Oral Surg Oral Med Oral Pathol Oral Radiol [Internet]. 2021;132(6):648-52.

Hirshberg A, Shnaiderman-Shapiro A, Kaplan I, Berger R. Metastatic tumors to the oral cavity-Pathogenesis and analysis of 673 cases. Oral Oncol. 2008;44(8):743-52.

Abro C, Sedhom R, Soni A, Markowski M. Cutaneous finger and tongue metastases in renal cell carcinoma. BMJ Case Rep. 2019;12(6):1-2.

Walsh MA, Quinn AJ, Mahesh B. Case report: renal cell carcinoma metastasis to the tongue. J Surg Case Reports. 2022;2022(12):1-3.

Kalinin Y, Correia-Neto IJ, do Nascimento SV, de Branco Gonçaves VC, de Andrade BAB, Nonaka CFW, Alves PM, Cunha JLS. Lingual metastasis as the first presentation of clear cell renal cell carcinoma: Report of a rare case clinically mimicking a benign lesion. Oral Oncol. 2023;137:106293.

Kweon HT, Yoo JS, Hong YT. Tongue Metastasis From Renal Cell Carcinoma: A Rare Case Presentation. Ear Nose Throat J. 2024.Published online.

Published

2024-07-06

Issue

Section

Caso Clínico

How to Cite

Metastasis of a renal tumor in the tongue: case report and literature update. (2024). Revista Da Faculdade De Odontologia - UPF, 29(1). https://doi.org/10.5335/rfo.v29i1.15654