Knowledge and confidence in the prescription of anti-inflammatory drugs among dentistry students: a cross-sectional analysis
DOI:
https://doi.org/10.5335/rfo.v30i1.16587Keywords:
Anti-inflammatory drugs, Dentistry students, PharmacotherapyAbstract
Objective: To evaluate the knowledge of Dentistry students at the State University of Feira de Santana (UEFS) regarding the pharmacotherapy of anti-inflammatory drugs, addressing pharmacodynamics, pharmacological classes, adverse reactions, and clinical indications, as well as exploring perceptions about teaching and learning in the area. Materials and Methods: An online self-administered questionnaire, containing 11 multiple-choice questions and 1 open-ended question, was applied to 180 students. The participants were grouped into intermediate semesters (IS; 5th to 7th) and final semesters (FS; 8th to 10th). The data were analyzed using descriptive and inferential statistical tests, with a significance level of 5%. Results: 46.1% of eligible students responded to the questionnaire. The overall average score was 5.76 out of 10, with no differences between the IS group (5.85) and the FS group (5.68; p = 0.237). Significant differences were observed in therapeutic approaches to oral pathologies: for recurrent aphthous stomatitis, the FS group performed better (p = 0.033; OR = 3.2), while for erosive lichen planus, the IS group had better results (p = 0.029; OR = 2.7). Additionally, there was a predominance of incorrect answers related to the adverse effects of anti-inflammatory drugs, with similar performance between the IS and FS groups (p>0.05). In self-perception, 49% of the IS group classified their knowledge as "insufficient," while 60% of the FS group considered it "sufficient." Conclusion: Although students demonstrated average general knowledge about anti-inflammatory drugs, the gaps in practical and advanced topics, especially related to adverse reactions and the management of patients with comorbidities, highlight the need to more effectively integrate theoretical and practical content in pharmacotherapy education.
Keywords: Anti-inflammatory drugs; Dentistry students; Pharmacotherapy
Downloads
References
Renton T. Dental (Odontogenic) Pain. Rev Pain. 2011;5(1):2–7. doi: 10.1177/204946371100500102.
Garcia DO, Pereira JAO, Andrade VEA, Xavier ALV, Brito WH, Oliveira Neto JQ, et al. O uso de corticoterapias no controle de parâmetros inflamatórios em cirurgia oral menor. Braz J Health Rev. 2020;3(4):8498–8511. doi: 10.34119/bjhrv3n4-102.
Monteiro B, Steagall PV. Antiinflammatory Drugs. Vet Clin North Am Small Anim Pract. 2019;49(6):993–1011. doi: 10.1016/j.cvsm.2019.07.009.
Ali KA, Maity A, Roy SD, Das Pramanik S, Das Pratim P, Shaharyar MdA. Insight into the mechanism of steroidal and non-steroidal anti-inflammatory drugs. In: Kazmi I, Karmakar S, Shaharyar MdA, Afzal M, Al-Abbasi FA, editors. Chapter 4. Academic Press. 2023:61–94. doi: 10.1016/B978-0-323-99855-0.00004-X.
Andrade ED, Groppo FS, Alan RS, Ranali J, Bentes APG, Ramacciato JC, et al. Terapêutica Medicamentosa em Odontologia. 3ª ed. São Paulo: Artes Médicas Ltda; 2014.
Bindu S, Mazumder S, Bandyopadhyay U. Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective. Biochem Pharmacol. 2020;180(1):114–147. doi: 10.1016/j.bcp.2020.114147.
Gupta, A., Bah, M. NSAIDs in the Treatment of Postoperative Pain. Curr Pain Headache Rep. 2016;20(11):62. doi: 10.1007/s11916-016-0591-7.
Poveda Roda R, Bagán JV, Jiménez Soriano Y, Gallud Romero L. Use of nonsteroidal antiinflammatory drugs in dental practice. A review. Medicina oral, patologia oral y cirugia bucal. 2007;12(1):E10–E18. doi: doi.org/10.1016/j.oooo.2014.12.002.
Berhouma L, Besbes A, Chokri A, Selmi J. Survey on Tunisian dentists’ anti-inflammatory drugs’ prescription in dental practice. Sci World J. 2021;2021:1–6. doi: 10.1155/2021/6633870.
Wallace HA, Basehore BM, Zito PM. Wound healing phases. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; [Accessed 2023 Jun 6]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK470443/.
Ouanounou A, Ng K, Chaban P. Adverse drug reactions in dentistry. Int Dent J. 2020;70(2):79-84. doi: 10.1111/idj.12540.
Chaudhari D, Chaudhary DH. Usage of non-steroidal anti-inflammatory drugs (NSAIDs) and their interaction with other concurrently used drugs in elderly patients. J Surv Fish Sci. 2023;10(4S):946–953. doi: 10.17762/sfs.v10i4S.1086.
Assunção TC, Rodrigues OMJ. Adverse effects in the indiscriminate use of non-steroidal anti-inflammatory drugs: Diclofenac versus Ibuprofen. Res Soc Dev. 2022;11(13):1–10. doi: 10.33448/rsd-v11i13.35937..
Bindua S, Mazumderb S, Bandyopadhyay U. Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective. Elsevier Inc. 2020;180:1–21. doi: 10.1016/j.bcp.2020.114147.
Ribeiro H, Rodrigues I, Napoleão L, Lira L, Marques D, Veríssimo M, et al. Non-steroidal anti-inflammatory drugs (NSAIDs), pain and aging: Adjusting prescription to patient features. Biomed Pharmacother. 2022;150:112958. doi: 10.1016/j.biopha.2022.112958.
Dathe K, Frank J, Padberg S, Hultzsch S, Beck E, Schaefer C. Fetal adverse effects following NSAID or metamizole exposure in the 2nd and 3rd trimester: an evaluation of the German Embryotox cohort. BMC Pregnancy Childbirth. 2022;22(1):666. doi: 10.1186/s12884-022-04986-4.
Batlouni M. Anti-inflamatórios não esteroides: Efeitos cardiovasculares, cérebro-vasculares e renais. Arq Bras Cardiol. 2010;94(4):556–63. doi: 10.1590/S0066-782X2010000400019.
World Health Organization. Guide to Good Prescribing. WHO/DAP/94.11. Available at: https://iris.who.int/bitstream/handle/10665/59001/WHO_DAP_94.11.pdf?sequence=1. Accessed December 19, 2024.
Gregson K, Romito LM, M.S., Garetto LP. Students’ Attitudes Toward Integrating Problem-Based Learning into a D.D.S. Pharmacology Curriculum. Journal of Dental Education. 2010;74:489-498. doi: 10.1002/j.0022-0337.2010.74.5.tb04895.
Pius S. Fasinu; Teresa W. Wilborn. Pharmacology education in the medical curriculum: Challenges and opportunities for improvement. Pharmacol Res Perspect. 2024;12:e1178. doi: 10.1002/prp2.1178.
Boaventura I, Costa J, Fernandes RM, Ferreira J. Perceção e Atitudes Sobre Prescrição Racional Durante a Formação Médica: Resultados de Grupos Focais com Estudantes de Medicina e Médicos Internos. Acta Médica Portuguesa. 2019;32(9):593. doi: https://doi.org/10.20344/amp.10945.
Gautam M, Shaw DH, Pate TD, Lambert HW. Pharmacology Education in North American Dental Schools: The Basic Science Survey Series. Journal of Dental Education. 2018;77(8):1013-1021. doi: 10.1002/j.0022-0337.2013.77.8.tb05570.x.
Breseghello I, Bezerra CTR, Faria MD, Antônio RC. Conhecimento de graduandos em odontologia sobre consulta odontológica de pacientes hipertensos, diabéticos e gestantes. Unifunec Cient Mult. 2021;10(12):1–14. doi: 10.24980/ucm.v10i12.3562.
Abdu N, Mosazghi A, Teweldemedhin S, Asfaha L, Teshale M, Kibreab M, et al. Non-steroidal anti-inflammatory drugs (NSAIDs): Usage and co-prescription with other potentially interacting drugs in elderly: A cross-sectional study. PLoS One. 2020;15(10):1–14. doi: 10.1371/journal.pone.0238868.
Brandão AGA, Trabuco PLS, Helfenstein AA. Conhecimento dos estudantes de odontologia sobre prescrição medicamentosa e suas alterações frente àpandemia do SARS-CoV-2. Diálogos & Ciência. 2022;1(2):199–210. doi: 10.7447/1678-0493.2022v2n2p199-210.
Park JS, Li J, Turner E, Page A, Kruger E, Tennant M. Medication knowledge among dental students in Australia – a cross-sectional study. J Dent Educ. 2020;84:799-804. doi: 10.1002/jdd.12167.
Roy A, Fathima F. Awareness of adverse effects of corticosteroids among dental undergraduates: A survey. Int J Sci Res. 2017;6(9):926–928.
Alqifari SF. Assessment of students’ knowledge and perception of pain and anti-inflammatory drug therapy in dental schools in Saudi Arabia. Futur Dent J. 2018;4(2):314–317. doi: 10.1016/j.fdj.2018.04.007.
Basirat M, Kia S J, Dadvar Z. General dentists’ knowledge and practice about corticosteroid prescription. Polish Annals of Medicine. 2019;26(2):114-119. doi:10.29089/2019.19.00072.
Motta ACF, Komesu MC, Grisi MF de M, Souza C da S, Roselino AMF, Migliari DA. Corticosteróide tópico oclusivo no tratamento de manifestações gengivais de doenças vesicobolhosas auto-imunes. An Bras Dermatol. 2006;81(3):283–285. doi: 10.1590/S0365-05962006000300011.
Oliveira GMR, Pereira HSC, Silva-Junior GO, Picciani BLS, Dias EP, Cantisano MH. Utilização de corticosteroide tópico oclusivo para o tratamento da gengivite descamativa: uma opção eficaz. Rev. Bras. Odontol. 2013;70(1):89-92. doi: 10.18363/rbo.v70n1.p.89.
Park JS, Daniel BK, Wong PY, Abbott PV, Ngo HC. Dental students' knowledge of and attitudes towards prescribing medication in Western Australia. Eur. J. Dent. Educ. 2023;27(2):287-295. doi: 10.1111/eje.12802.
Barry OP, O'Sullivan E. Comparison of dental students' performances and perceptions in preclinical and clinical pharmacology in an Irish dental school. Eur J Dent Educ. 2017;21:e19-e28. doi: 10.1111/eje.12210.
Brinkman DJ, Nijland N, van Diermen DE, Bruers JJM, Ligthart WSM, Rietveld PJ, et al. Are Dutch dental students and dental care providers competent prescribers of drugs? Eur J Oral Sci. 2019;127(6):531–538. doi: 10.1111/eos.12658.
Assunção ÉLF, Júnior RM, Ferreira FA. Conhecimento dos acadêmicos de odontologia acerca da prescrição de fármacos. Rev Bionorte. 2017;6(1):23–33. doi: 10.1111/eos.12658.
Chen D, Yue H, Liu S, Meng L, Yin W. The introduction of team-based learning into the clinical pharmacology section of the endodontics clinical course. Clin Exp Pharmacol Physiol. 2022;49(9):998-1001. doi: 10.1111/1440-1681.13684.
Downloads
Published
Issue
Section
License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

This work is licensed under aCreative Commons Atribuição-NãoComercial-SemDerivações 4.0 Internacional.
